talacotuzumab (JNJ-56022473) - J&J
CSL: R&D Investor Briefing (CSL Behring) - Jan 9, 2016 - “Manageable safety profile: Pre-medication with steroids required to prevent infusion reactions”; “PD effects confirming CD123-targeted ADCC”; “Rapid and full depletion of basophils and pDCs: Sustained depletion at CSL362 dose levels ≥ 3 mg/kg”; “Saturation of CD123 receptor on monocytes at CSL362 dose levels ≥ 3 mg/kg (trough concentration > 3μg/ml)”; “Conversion of MRD seen in a subset of pts treated with CSL362” 
P1 data Acute Myelogenous Leukemia
http://www.csl.com.au/docs/408/905/CSL%20Investor%20Briefing%20Dec%202015.pdf
 
Jan 9, 2016
 
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